קורות חיים - Curriculum vitae

 

 

Ohad Ilovich, Ph.D.

978 Mangrove Avenue, Sunnyvale, CA 94086. Cell 408-680-4753. ilovich@stanford.edu

 

Summary Statement

Experienced postdoc in the fields of pharmaceuticals, organic chemistry and radiochemistry (including work with fluorine-18, carbon-11 and copper-64) and molecular imaging. Experience in all levels of development, from literary mining for new targets, tracer development, pre-clinical (in vitro and in vivo) evaluations, Structure-activity relationship and pharmacokinetic profiling and translation clinical translation.

Interested in development of novel tracers for molecular imaging modalities with a focus on PET and SPECT technologies.

 

Education

2012-               Postdoctoral fellow in the Gambhir group, department of Radiology, Stanford University. Research focus on the use of antibody fragments as companion diagnostics for antibody-drug conjugates and their clinical translation

 

2006-2011       Ph.D in Radiochemistry and molecular imaging, Cyclotron unit, School of pharmacy, Hebrew University, Jerusalem, Israel.

Thesis title: Novel Positron Emission Tomography (PET) agents for in vivo imaging of angiogenic processes and myocardial perfusion

Research focused on two fields, imaging angiogenesis and myocardial perfusion imaging. In the field of angiogenesis, research included development of 18F and 11C labeled small molecule TKIs of VEGFR-2 for imaging angiogenesis. In the field of MPI research included the development of several derivatives of 11C and 18F labeled lipophilic ammonium salt derivatives, evaluation of SAR and preclinical evaluation.

 

2004-2005       M.Sc. (magna cum lauda), Medicinal chemistry, School of pharmacy, Hebrew University, Jerusalem, Israel.

Thesis title: The synthesis of 3α and 3β hydroxy steroids with cardio-active qualities.

Research focused on the development of novel derivatives of Ouabain with increased therapeutic window and decreased toxicity. Involved multi-step organic synthesis in the fields of steroid and heterocyclics.

 

2000-2004       B.Pharm (magna cum lauda), School of pharmacy, Hebrew University, Jerusalem, Israel.

 

Job experience

2005-2011 – Radiopharmacist/Radiochemist, Cyclotron unit, School of pharmacy, Hebrew University, Jerusalem, Israel.

Cyclotron operation, synthesis and quality control validation of PET tracers (e.g, FDG, choline, acetate) for the clinic.

 

2004-2008 – Pharmacist in a large pharmacy chain.

 

2001-2004 – Lab assistant in Prof. Joseph Deutsch’s laboratory, School of pharmacy, Hebrew University, Jerusalem, Israel.

Organic synthesis of steroids and heterocycles

 

 

Awards and grants

2011                Israeli Science Foundation grant

2008-2011       The Hoffman Leadership and Responsibility program

2006                Israeli Science Foundation grant

2005                Pharmacologist Association of Israel Achievement award

2001-2003       Dean’s Excellence Award

2000                Jerusalem grant

 

Languages

Hebrew – Native tongue

English – Very high level

 

Papers in Peer-Review Journals

  1. Ilovich O., Abourbeh G., Bocher M., Freedman N., Biluar H., Dotan S., Danenberg C. and Mishani E. Structure–Activity Relationship and Preclinical Evaluation of Carbon-11-Labeled Ammonium Salts as PET–Myocardial Perfusion Imaging Agents. Mol. Imaging Biol. 2012, 14(5): 625-36.
  2. Sand F. W., Hornblad A., Johansson J. K., Loren C., Edsbagge J., Stahlberg, A., Magenheim J., Ilovich O., Mishani E., Dor Y., Ahlgren U. and Semb H. Growth-limiting role of endothelial cells in endoderm development. Dev Biol 2011, 352 (2), 267-77
  3. Lazarus A., Del-Mora, P. M., Ilovich O., Mishani E., Warburton D. and Keshet E. A perfusion-independent role of blood vessels in determining branching stereotypy of lung airways. Development 2011, 138 (11), 2359-68
  4. Ilovich O., Billauer H., Dotan S., Freedman N., Bocher M, and Mishani E. Novel and simple carbon-11 labeled ammonium salts as PET agents for myocardial perfusion imaging. Mol. Imaging Biol. 2011, 13, 128-139
  5. Ilovich O., Billauer H., Dotan S. and Mishani E. Labeled 3-aryl-4-indolylmaleimide derivatives and their potential as angiogenic PET biomarkers. Bioorg Med Chem. 2010, 18(2), 612-620
  6. Ilovich O., Åberg O, Långström B. and Mishani E. Rhodium-mediated [11C]Carbonylation:  A library of N-Phenyl-N’-{4-(4-quinolyloxy)-phenyl}-[11C]-urea Derivatives as Potential PET Angiogenic Probes. J. Label Compd. Radiopharm 2009, 52 151–157
  7. Ilovich O., Jacobson O., Aviv Y., Litchi A., Chisin R., and Mishani E. Formation of fluorine-18 labeled diaryl ureas-labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis. Bioorg Med Chem. 2008, 16(8), 4242-4251
  8. Deutsch J., Jang H. G., Mansur N., Ilovich O., Shpolansky U., Galili D., Feldman T., Rosen H. and Lichtstein D. 4-(3'a15'b-Dihydroxy-5'b-estran-17'b-yl)furan-2-methyl alcohol (13-03), An Anti-Digoxin Agent with a Novel Mechanism of Action. J. Med. Chem. 2006, 49, 600-606
  9. Ilovich O. and Deutsch J., A selective synthesis of 4-bromo-2-furancarboxaldehyde and its pinacolborane derivative. J. Heter. Chem., 2005, 42, 1409-1411

 

 

ABSTRACTS OF PAPERS PRESENTED IN SCIENTIFIC MEETINGS (Peer review)

  1. Samar Dissoki, Smadar Elmachily, Sharon Dotan, Hana Billauer, Ohad Ilovich, Galith Abourbeh, Eyal Mishani, Aviv Hagooly. Can Radiolabeled GE11 Peptide Serve as a marker for Imaging the Epidermal Growth Factor Receptor (EGFR)? World Molecular Imaging Congress, Kyoto, Japan 2010. (poster)
  2. Amit Hetsron, Ohad Ilovich, Sassy Cohen, Eyal Mishani and Aviv Hagooly. Automated Radiosynthesis of [18F]Fluoroethylazide ([18F]FEA) World Molecular Imaging Congress, Kyoto, Japan 2010. (poster)
  3. Ohad Ilovich, Hana Billauer, Sharon Dotan, Moshe Bocher, Nanette M.T. Freedman, Haim Danenberg , Galith Abourbeh and Eyal Mishani. Are Carbon-11 Labeled Ammonium Salts Superior to 99mTc-Mibi as Myocardial Perfusion Imaging Agents? World Molecular Imaging Congress, Kyoto, Japan 2010. (poster)
  4. Ohad Ilovich, Renana Eshet, Hana Billauer, and Eyal Mishani. Radiopharmaceutical approaches for the imaging of angiogenic processes in cancer. Israeli Society of Nuclear Imaging, The dead sea, Israel 2009. (Lecture)
  5. Ohad Ilovich, Ola Åberg, Bengt Långström and Eyal Mishani. Radiopharmaceutical Strategies for the imaging of Angiogenesis in Cancer. World Molecular Imaging Congress, Nice, France, 2008. (Lecture)

 

Patents

1)      Mishani E., Ilovich O., Billauer H., Dotan S., Danenberg H., Bocher M., Abourbeh G., Freedman N. Molecular Imaging Agents. 20110293519